Connor Swindells as Adam Groff, the son of the former headmaster of Moordale who has a complicated relationship with Eric. He tries to find his place at Cavendish and deal with his family issues
Mimi Keene as Ruby Matthews, one of the most popular girls at Moordale who develops a crush on Otis after they have sex in the third season. She follows him to Cavendish and tries to get his attention
Dua Saleh as Cal Bowman, a non-binary student who transfers to Cavendish from Moordale. They are confident and outspoken about their gender identity and sexuality. They befriend Jackson and help him discover himself
Gillian Anderson as Jean Milburn, Otis’s mother who is a sex therapist and radio host. She has a newborn daughter, Joy, with Jakob, Maeve’s estranged father. She suffers from postpartum depression and struggles to bond with her baby